KMID : 1038120140470050383
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Clinical Endoscopy 2014 Volume.47 No. 5 p.383 ~ p.388
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Molecular Imaging for Theranostics in Gastroenterology: One Stone to Kill Two Birds
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Ko Kwang-Hyun
Kwon Chang-Il Park Jong-Min Lee Hoo-Geun Han Na-Young Hahm Ki-Baik
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Abstract
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Molecular imaging in gastroenterology has become more feasible with recent advances in imaging technology, molecular genetics, and next-generation biochemistry, in addition to advances in endoscopic imaging techniques including magnified high-resolution endoscopy, narrow band imaging or autofluorescence imaging, flexible spectral imaging color enhancement, and confocal laser endomicroscopy. These developments have the potential to serve as ¡°red flag¡± techniques enabling the earlier and accurate detection of mucosal abnormalities (such as precancerous lesions) beyond biomarkers, virtual histology of detected lesions, and molecular targeted therapy?the strategy of ¡°one stone to kill two or three birds¡±; however, more effort should be done to be ¡°blue ocean¡± benefit. This review deals with the introduction of Raman spectroscopy endoscopy, imaging mass spectroscopy, and nanomolecule development for theranostics. Imaging of molecular pathological changes in cells/tissues/organs might open the ¡°royal road¡± to either convincing diagnosis of diseases that otherwise would only be detected in the advanced stages or novel therapeutic methods targeted to personalized medicine.
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KEYWORD
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Molecular imaging, Spectrum analysis, Raman, Imaging mass spectroscopy, Theranostics, Individualized medicine
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